Cholinesterase: substrate inhibition and substrate activation

  title={Cholinesterase: substrate inhibition and substrate activation},
  author={Elsa Reiner and Vera Simeon-Rudolf},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
The relationship between activities and substrate concentrations (pS-curves) was analysed for reactions of acetylcholinesterase (EC and butyrylcholinesterase (EC Catalytic constants Km, Kss, Vm, n and b were calculated from the Michaelis, Haldane, Hill and Webb equations in order to assess whether a given substrate also acts as an inhibitor or activator. It is suggested that the term substrate inhibition should only be attributed to substrates revealing bell-shaped pS-curves… CONTINUE READING