Cholinesterase: substrate inhibition and substrate activation

@article{Reiner2000CholinesteraseSI,
  title={Cholinesterase: substrate inhibition and substrate activation},
  author={Elsa Reiner and Vera Simeon-Rudolf},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2000},
  volume={440},
  pages={R118-R120}
}
The relationship between activities and substrate concentrations (pS-curves) was analysed for reactions of acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8). Catalytic constants Km, Kss, Vm, n and b were calculated from the Michaelis, Haldane, Hill and Webb equations in order to assess whether a given substrate also acts as an inhibitor or activator. It is suggested that the term substrate inhibition should only be attributed to substrates revealing bell-shaped pS-curves… CONTINUE READING