Cholinesterase: phenotyping and genotyping.

@article{Goodall2004CholinesterasePA,
  title={Cholinesterase: phenotyping and genotyping.},
  author={Roberta Goodall},
  journal={Annals of clinical biochemistry},
  year={2004},
  volume={41 Pt 2},
  pages={98-110}
}
The plasma enzyme butyrylcholinesterase (BChE) is of clinical interest because of the occurrence of genetic variants with decreased ability to hydrolyse, and therefore inactivate, muscle-relaxant drugs such as suxamethonium. Analysis of BChE involves the determination of both enzyme activity and biochemical phenotypes which are used to determine the risk of so-called 'scoline apnoea'. Problems in analysis arise from both the lack of a universally accepted reference method and the variety of… CONTINUE READING

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