Cholinergic treatment of an amnestic man with a basal forebrain lesion: theoretical implications.

@article{Chatterjee1993CholinergicTO,
  title={Cholinergic treatment of an amnestic man with a basal forebrain lesion: theoretical implications.},
  author={Anjan Chatterjee and Mary K Morris and Dawn Bowers and David J Williamson and Leilani Doty and Kenneth M Heilman},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1993},
  volume={56 12},
  pages={1282-9}
}
Cholinergic deficient states, such as in Alzheimer's disease, are associated with amnesia. Therapeutic trials with cholinergic augmentation in Alzheimer's disease have had only equivocal results, but mechanisms other than cholinergic deficiency may contribute to the memory deficit. Normally the diagonal band of Broca provides much of the hippocampal cholinergic input. To learn if amnesia secondary to cholinergic deficiency can be ameliorated by cholinergic augmentation, we treated an amnestic… CONTINUE READING