Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain

@article{Woolf1986CholinergicSI,
  title={Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain},
  author={Nancy J. Woolf and Larry L. Butcher},
  journal={Brain Research Bulletin},
  year={1986},
  volume={16},
  pages={603-637}
}
The ascending cholinergic projections of the pedunculopontine and dorsolateral tegmental nuclei, referred to collectively as the pontomesencephalotegmental (PMT) cholinergic complex, were investigated by use of fluorescent tracer histology in combination with choline-O-acetyltransferase (ChAT) immunohistochemistry and acetylcholinesterase (AChE) pharmacohistochemistry. Propidium iodide, true blue, or Evans blue was infused into the anterior, reticular, mediodorsal, central medial, and posterior… Expand
Cholinergic systems in the rat brain: IV. descending projections of the pontomesencephalic tegmentum
TLDR
Fluorescent tracers used in combination with AChE pharmacohistochemistry corroborated these projections and provided evidence for cholinergic pontomesencephalic projections to the lateral reticular nucleus and inferior olive. Expand
Afferents to the basal forebrain cholinergic cell area from pontomesencephalic—catecholamine, serotonin, and acetylcholine—neurons
TLDR
Results demonstrate that pontomesencephalic monoamine neurons project in large numbers up to the basal forebrain cholinergic neurons and may represent a major component of the ventral tegmental pathway that forms the extra-thalamic relay from the brainstem through the basalForebrain to the cerebral cortex. Expand
Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat
TLDR
Findings suggest the laterodorsal tegmental nucleus to be a highly differentiated part of the ascending "reticular activating" system, concerned not only with specific cortical and thalamic regions, especially those associated with the limbic system, but also with the basal ganglia, and visual mechanisms. Expand
Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat
TLDR
Brainstem afferents to the magnocellular basal forebrain were studied by using tract tracing, immunohistochemistry and extracellular recordings in the rat to find labelled neurons in the substantia nigra pars compacta, mesencephalic and pontine reticular formation. Expand
Projections of cholinergic and non-cholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey
TLDR
The striking retrograde cell labeling observed after injections in nuclei with associative functions and widespread cortical projections was due to massive afferentation from non-cholinergic parts of the midbrain and pontine reticular formation, on both ipsi- and contralateral sides. Expand
Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups
TLDR
Findings indicate that the diverse physiological and behavioral effects attributed to the activity of pontomesencephalic cholinergic neurons should not be dissociated from their activating effects in the thalamus. Expand
Cholinergic and non-cholinergic projections from the upper brainstem core to the visual thalamus in the cat
TLDR
Findings reveal the existence of a prominent cholinergic projection from the brainstem reticular formation to the visual thalamic nuclei, probably involved in phasic and tonic events of activated behavioral states. Expand
Basal forebrain cholinergic and noncholinergic projections to the thalamus and brainstem in cats and monkeys
TLDR
The findings reveal the existence of cholinergic and noncholinergic basal forebrain projections to the thalamus and the brainstem in both cats and macaque monkeys and suggest that these projections may play a crucial role in the control of thalamic functions in mammals. Expand
Collateral axons of cholinergic pontine neurones projecting to midline, mediodorsal and parafascicular thalamic nuclei in the rat
TLDR
The anatomical findings, taken together with functional evidence, suggest that cholinergic terminals arising from LDTg are involved in coordinating thalamic mechanisms of brain state control; and in regulating dopaminergic pathways, both directly and via the thalamus. Expand
Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area
TLDR
The concept that this cholinergic group is functionally organized in a manner which selectively innervates motor (SN) and limbic (VTA) dopaminergic nuclei is supported. Expand
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TLDR
No simple topographic pattern emerged to explain the cholinergic innervation of the limbic telencephalon, although an essentially reverse rostrocaudal organization was observed for afferents to the cingular region. Expand
Cholinergic systems in the rat brain: II. Projections to the interpeduncular nucleus
TLDR
The cholinergic innervation of the interpeduncular nucleus was investigated by use of fluorescent tracer histology in combination with choline-O-acetyltransferase (ChAT) immunohistochemistry and acetylcholinesterase (AChE) pharmacohistochemical to suggest that ChAT-positive cells in the basal forebrain and dorsolateral tegmental nucleus derive primarily from Chat-positive neurons projecting to the interpinguncular nuclei. Expand
Cholinergic projections from the midbrain and pons to the thalamus in the rat, identified by combined retrograde tracing and choline acetyltransferase immunohistochemistry
TLDR
Findings demonstrate direct cholinergic projections to the thalamus from neurons in several regions in the tegmentum and suggest that tegmental projections in the midbrain and pons are predominantlyCholinergic. Expand
Topographical organization of the brainstem afferents to the lateral posterior-pulvinar thalamic complex in the cat
TLDR
Following stereotaxic injections of horseradish peroxidase in the dorsal thalamus of the cat, labelled neurons were found in the superficial layers of the superior colliculus and in the brainstem, and it was concluded that the rostrointermediate subdivision of the lateralis posterior-pulvinar complex receives most of its connections from the nucleus tegmenti pedunculopontinus and from the other brainstem nuclei. Expand
Efferent connections of the substantia nigra and ventral tegmental area in the rat
TLDR
Isotope injections confined to the pars reticulata label sparse nigrostriatal fibers, and numerous nigrothalamic fibers ascending mainly to the nucleus ventromedialis and in lesser number to the parafascicular nucleus and the paralamellar zone of the nucleus mediodorsalis. Expand
Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis
The morphologies, intercellular organization, and cortical projection patterns of putative cholinergic neurons in the basal forebrain of the rat were examined by use of fluorescent tracer histologyExpand
The ventral pallidal projection to the mediodorsal thalamus: a study with fluorescent retrograde tracers and immunohistofluorescence
  • W. Young, G. Alheid, L. Heimer
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
TLDR
Rat basal forebrain projections to the mediodorsal thalamic nucleus (MD) are examined by making injections of retrogradely transported fluorescent tracers into the MD and a large number of labeled cells are present in the olfactory tubercle, and these cells are almost without exception located in dense GAD- positive ventral pallidal areas rather than in striatal regions of the tubercle. Expand
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey
The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradishExpand
Mesencephalic and diencephalic afferents to the superior colliculus and periaqueductal gray substance demonstrated by retrograde axonal transport of horseradish peroxidase in the cat
TLDR
In the cats submitted to injections in the central gray substance, labeled cells were consistently found in the contralateral superior colliculus, the mesencephalic reticular formation, substantia nigra parts reticulata, zona incerta and various hypothalamic areas, especially the ventromedial nucleus. Expand
Topographic organization of the brainstem afferents to the mediodorsal thalamic nucleus
TLDR
The findings show the MD as a thalamic link of three different groups of brainstem structures projecting to different cortical areas with different functional significance. Expand
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