Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure.

@article{Behling2003CholinergicSW,
  title={Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure.},
  author={Alice Behling and Ruy Silveira Moraes and Luis Eduardo P. Rohde and Elton Luiz Ferlin and Antonio C L N{\'o}brega and Jorge Pinto Ribeiro},
  journal={American heart journal},
  year={2003},
  volume={146 3},
  pages={494-500}
}
BACKGROUND Increased ventricular arrhythmia density and reduced heart rate variability are associated with risk of death in patients with heart failure. Cholinesterase inhibition with pyridostigmine bromide increases heart rate variability in normal subjects, but its effect on patients with heart failure is unknown. In this study, we tested the hypothesis that short-term administration of pyridostigmine bromide, a cholinesterase inhibitor, reduces ventricular arrhythmia density and increases… CONTINUE READING