Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

@article{Dulawa2018CholinergicRO,
  title={Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics},
  author={Stephanie C. Dulawa and David S. Janowsky},
  journal={Molecular Psychiatry},
  year={2018},
  volume={24},
  pages={694-709}
}
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have been postulated. Over 50 years ago, clinical studies suggested that increases in central acetylcholine could lead to depressed mood. Evidence has continued to accumulate suggesting that the cholinergic system has a important role in mood regulation… CONTINUE READING
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