Cholinergic regulation of epithelial ion transport in the mammalian intestine.

  title={Cholinergic regulation of epithelial ion transport in the mammalian intestine.},
  author={Christina L. Hirota and D M McKay},
  journal={British journal of pharmacology},
  volume={149 5},
Acetylcholine (ACh) is critical in controlling epithelial ion transport and hence water movements for gut hydration. Here we review the mechanism of cholinergic control of epithelial ion transport across the mammalian intestine. The cholinergic nervous system affects basal ion flux and can evoke increased active ion transport events. Most studies rely on measuring increases in short-circuit current (ISC = active ion transport) evoked by adding ACh or cholinomimetics to intestinal tissue mounted… CONTINUE READING
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