Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.

@article{Sepsova2015CholinergicPO,
  title={Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.},
  author={V. Sepsova and J. Karasova and G. Tobin and D. Jun and J. Kor{\'a}be{\vc}n{\'y} and Pavla {\vC}{\'a}belov{\'a} and Katerina Janska and J. Krů{\vs}ek and Kristyna Skrenkova and K. Ku{\vc}a and O. Soukup},
  journal={General physiology and biophysics},
  year={2015},
  volume={34 2},
  pages={
          189-200
        }
}
Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Overstimulation of cholinergic receptors (muscarinic and nicotinic) by excessive amounts of ACh causes several health problems and may even cause death. Reversible AChE inhibitors play an important role in prophylaxis against nerve agents. The presented study investigated whether 7-methoxytacrine (7-MEOTA) and 7-MEOTA-donepezil derivatives… Expand
Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs.
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
...
1
2
...

References

SHOWING 1-10 OF 39 REFERENCES
Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment.
  • J. Bajgar
  • Medicine
  • Advances in clinical chemistry
  • 2004
Complex view on poisoning with nerve agents and organophosphates.
Donepezil, but not galantamine, blocks muscarinic receptor‐mediated in vitro and in vivo responses
...
1
2
3
4
...