Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome.

@article{Pires2005CholinergicPA,
  title={Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome.},
  author={Rita Gomes Wanderley Pires and S{\'i}lvia Rejane Castanheira Pereira and Ieda de F{\'a}tima Oliveira-Silva and Glaura C. Franco and Angela Maria Ribeiro},
  journal={Behavioural brain research},
  year={2005},
  volume={162 1},
  pages={11-21}
}
This is a factorial (2 x 2 x 2) spatial memory and cholinergic parameters study in which the factors are chronic ethanol, thiamine deficiency and naivety in Morris water maze task. Both learning and retention of the spatial version of the water maze were assessed. To assess retrograde retention of spatial information, half of the rats were pre-trained on the maze before the treatment manipulations of pyrithiamine (PT)-induced thiamine deficiency and post-tested after treatment (pre-trained… CONTINUE READING