Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

@inproceedings{Jeong2015CholinergicNI,
  title={Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism},
  author={Jae Hoon Jeong and Dong Kun Lee and Cl{\'e}mence Blouet and Henry H. Ruiz and Christoph Buettner and S. Chua and Gary J Schwartz and Young-Hwan Jo},
  booktitle={Molecular metabolism},
  year={2015}
}
OBJECTIVE Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function and synaptic connectivity of input from DMH cholinergic neurons to sympathetic premotor neurons in the raphe pallidus (Rpa). METHODS In order to selectively manipulate DMH cholinergic neuron activity, we generated transgenic mice expressing channelrhodopsin… CONTINUE READING

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