Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons.

  title={Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons.},
  author={Chun Yang and James Timothy McKenna and Janneke C. Zant and Stuart Winston and Radhika Basheer and Ritchie E Brown},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={34 8},
The basal forebrain (BF) plays an important role in the control of cortical activation and attention. Understanding the modulation of BF neuronal activity is a prerequisite to treat disorders of cortical activation involving BF dysfunction, such as Alzheimer's disease. Here we reveal the interaction between cholinergic neurons and cortically projecting BF GABAergic neurons using immunohistochemistry and whole-cell recordings in vitro. In GAD67-GFP knock-in mice, BF cholinergic (choline… CONTINUE READING
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