Cholinergic neuronal deficits in CADASIL.

  title={Cholinergic neuronal deficits in CADASIL.},
  author={Jessica S Keverne and Wee Chuang R Low and Iryna Ziabreva and Jenny A Court and Arthur Ernest Oakley and Raj N Kalaria},
  volume={38 1},
BACKGROUND AND PURPOSE Previous evidence from MRI and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). METHODS As a measure of cholinergic function, we assessed choline acetyltransferase (ChAT) activities in the frontal and temporal neocortices and the immunocytochemical distribution of ChAT and p75 neurotrophin receptor (P75(NTR)) by in vitro imaging in the… CONTINUE READING
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