Cholinergic modulation of response gain in the primary visual cortex of the macaque.

@article{Soma2012CholinergicMO,
  title={Cholinergic modulation of response gain in the primary visual cortex of the macaque.},
  author={Shogo Soma and Satoshi Shimegi and Hironobu Osaki and Hiromichi Sato},
  journal={Journal of neurophysiology},
  year={2012},
  volume={107 1},
  pages={283-91}
}
ACh modulates neuronal activity throughout the cerebral cortex, including the primary visual cortex (V1). However, a number of issues regarding this modulation remain unknown, such as the effect and its function and the receptor subtypes involved. To address these issues, we combined extracellular single-unit recordings and microiontophoretic administration of ACh and measured V1 neuronal responses to drifting sinusoidal grating stimuli in anesthetized macaque monkeys. ACh was found to have… CONTINUE READING