Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors.

  title={Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors.},
  author={R. Douglas Shytle and Takashi Mori and Kirk Townsend and Martina Vendrame and Nan Sun and Jin Zeng and Jared Ehrhart and Archie A. Silver and Paul R. Sanberg and Jun Tan},
  journal={Journal of neurochemistry},
  volume={89 2},
Almost all degenerative diseases of the CNS are associated with chronic inflammation. A central step in this process is the activation of brain mononuclear phagocyte cells, called microglia. While it is recognized that healthy neurons and astrocytes regulate the magnitude of microglia-mediated innate immune responses and limit excessive CNS inflammation, the endogenous signals governing this process are not fully understood. In the peripheral nervous system, recent studies suggest that an… CONTINUE READING
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