Cholinergic mechanisms in depression

  title={Cholinergic mechanisms in depression},
  author={Steven C. Dilsaver},
  journal={Brain Research Reviews},
Evidence supporting a cholinergic hypothesis of depression is presented. First, cholinergic overdrive produces behavioral, neuroendocrine, and polysomnographic features of melancholia, and melancholics exhibit state-independent supersensitivity to cholinergic overdrive. Drugs inducing up-regulation and supersensitivity of cholinergic systems produce behavioral, polysomnographic, and neuroendocrine effects of melancholia when withdrawn. These observations also implicate cholinergic system… CONTINUE READING


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