Cholinergic mechanism underlying prepulse inhibition of the startle response in rats.

@article{Bosch2008CholinergicMU,
  title={Cholinergic mechanism underlying prepulse inhibition of the startle response in rats.},
  author={Daniel Bosch and Susanne Schmid},
  journal={Neuroscience},
  year={2008},
  volume={155 1},
  pages={326-35}
}
Startle responses are attenuated by prepulse inhibition (PPI), which is considered to reflect a sensorimotor gating mechanism and is impaired in patients suffering from schizophrenia. A midbrain circuit that mediates PPI in rats has been proposed and behavioral experiments have indicated an important role of acetylcholine and GABA in inhibiting startle. We here test the hypothesis that activation of the midbrain neurons can inhibit startle signaling through a cholinergic mechanism. We have… CONTINUE READING
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