Cholinergic interneurons control the excitatory input to the striatum.

  title={Cholinergic interneurons control the excitatory input to the striatum.},
  author={Pavel Pakhotin and Enrico Bracci},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 2},
How the extent and time course of presynaptic inhibition depend on the action potentials of the neuron controlling the terminals is unknown. We investigated this issue in the striatum using paired recordings from cholinergic interneurons and projection neurons. Glutamatergic EPSCs were evoked in projection neurons and cholinergic interneurons by stimulation of afferent fibers in the cortex and the striatum, respectively. A single spike in a cholinergic interneuron caused significant depression… CONTINUE READING
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