Cholinergic inhibition of short (outer) hair cells of the chick's cochlea.

  title={Cholinergic inhibition of short (outer) hair cells of the chick's cochlea.},
  author={Paul Albert Fuchs and Bruce W Murrow},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={12 3},
Cochlear hair cells are thought to be inhibited by the release of ACh from efferent neurons. Several studies have implicated Ca2+ as a postsynaptic intermediary in hair cell inhibition, but its role remains unproven. We have made whole-cell, tight-seal recordings from single short hair cells (the avian analog of outer hair cells in the mammalian cochlea), isolated from the chick's cochlea, to determine the mechanism of cholinergic inhibition. These cells hyperpolarized upon exposure to ACh… CONTINUE READING
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