Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia.

@article{Hirano2010CholinergicII,
  title={Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia.},
  author={Shigeki Hirano and Hitoshi Shinotoh and Hitoshi Shimada and Akiyo Aotsuka and Noriko Tanaka and Tsuneyoshi Ota and Koichi Sato and Hiroshi Ito and Satoshi Kuwabara and Kiyoshi Fukushi and Toshiaki Irie and Tetsuya Suhara},
  journal={Brain : a journal of neurology},
  year={2010},
  volume={133 Pt 7},
  pages={2058-68}
}
Corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia are all part of a disease spectrum that includes common cognitive impairment and movement disorders. The aim of this study was to characterize brain cholinergic deficits in these disorders. We measured brain acetylcholinesterase activity by [11C] N-methylpiperidin-4-yl acetate and positron emission tomography in seven patients with corticobasal syndrome (67.6+/-5.9 years), 12 with progressive supranuclear palsy… CONTINUE READING

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