• DOI:10.1007/s00213-005-0043-2
• Corpus ID: 21341306

Cholinergic enhancement of episodic memory in healthy young adults

@article{Grn2005CholinergicEO,
  title={Cholinergic enhancement of episodic memory in healthy young adults},
  author={Georg Gr{\"o}n and Matthias Kirstein and Axel Thielscher and Matthias W Riepe and Manfred Spitzer},
  journal={Psychopharmacology},
  year={2005},
  volume={182},
  pages={170-179}
}

• G. Grön, M. Kirstein, +2 authors M. Spitzer
• Published 14 July 2005
• Psychology, Biology, Medicine
• Psychopharmacology

RationaleAcetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects.ObjectiveThis study evaluated the effects of donepezil, an inhibitor of AchE, on cognitive performance in young and healthy subjects.MethodsWe used a randomised double-blind parallel group placebo-controlled repeated measures design to investigate changes of cognitive functions in a group of 30 young healthy male subjects (mean age 23.9 years±2.24 SD) upon application of donepezil or placebo for 30 days. Attentional and executive functions, visual and verbal short-term and working memory, semantic memory, as well as verbal and visual episodic memory were investigated using an extensive neuropsychological test battery.ResultsTime-by-group interactions demonstrated significant drug effects that were specific to episodic memory in both the verbal and visual domain. Additionally, donezepil significantly improved long-term visual episodic recall. In none of the other functions under investigation any significant treatment effects were observed.ConclusionGiven this specific drug effect and the well-known relevance of the hippocampal region for episodic memory, we conclude that this region appears to be the major target of cholinergic enhancement in healthy subjects due to long-term inhibition of AchE.