Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.

@article{Matsuoka1989CholinergicDO,
  title={Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.},
  author={Ichiro Matsuoka and Noboru Mizuno and K. Kurihara},
  journal={Brain research},
  year={1989},
  volume={502 1},
  pages={53-60}
}
The effects of retinoic acid (RA), a naturally occurring metabolite of vitamin A, on the growth, morphology and neurochemical differentiation of the PC12 clone of rat pheochromocytoma cells were investigated. RA added to the medium inhibited the growth of PC12 cells in a dose-dependent manner up to 10 microM without affecting their morphology. In PC12 cells… CONTINUE READING