Cholinergic differentiation in neurogenic basal forebrain cultures.

  title={Cholinergic differentiation in neurogenic basal forebrain cultures.},
  author={M Martinic and Mary P. Lambert and Shao-bing Hua and William L. Klein},
  journal={Journal of neurobiology},
  volume={23 3},
To study early events in the central nervous system (CNS) cholinergic development, cells from rat basal forebrain tissue were placed in culture at an age when neurogenesis in vivo is still active [embryonic day (E) 15]. The rapid mortality of these cells in defined medium, with 50% mortality after 5-10 h, was blocked completely by soluble proteins from the… CONTINUE READING