Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation.


Chelatable zinc has repeatedly been associated with hippocampal mossy fibers, but the neurobiological functions of the zinc have remained unclear. Zinc is a constituent of the 7S Nerve Growth Factor (NGF) molecule. The hippocampal area is rich in neurotrophic factors and cholinergic deafferentation of the hippocampus appears to activate these neurotrophic… (More)