Cholinergic deafferentation of prefrontal cortex increases sensitivity to cross-modal distractors during a sustained attention task.

@article{Newman2008CholinergicDO,
  title={Cholinergic deafferentation of prefrontal cortex increases sensitivity to cross-modal distractors during a sustained attention task.},
  author={Lori A. Newman and J. Kent McGaughy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 10},
  pages={
          2642-50
        }
}
The effects of restricted cholinergic deafferentation of prefrontal cortex in rats on sustained attention were assessed. Attentional demands were increased by presentation of distractor stimuli in a different modality (auditory) or the same modality (visual) as target stimuli. Additionally, the effects of the regularity of the distractor on rats' ability to disregard this stimulus were assessed by testing different frequencies of stimuli for each modality. Cholinergically lesioned rats were… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Sustained visual attention performance-associated prefrontal neuronal activity: evidence for cholinergic modulation.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Neural coding of behavioral relevance in parietal cortex

  • Current Opinion in Neurobiology
  • 2003
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL