Cholinergic constriction in the general circulation and its role in coronary artery spasm.

@article{Kalsner1989CholinergicCI,
  title={Cholinergic constriction in the general circulation and its role in coronary artery spasm.},
  author={Stanley Kalsner},
  journal={Circulation research},
  year={1989},
  volume={65 2},
  pages={237-57}
}
The release of acetylcholine from autonomic nerves in those tissues that receive a cholinergic innervation is widely believed to dilate blood vessels. Exogenously administered acetylcholine in vivo does dilate vascular beds and produce hypotension; however, this latter effect is indirect and probably the result of liberation of endothelium-derived relaxing factor (EDRF) from endothelial cells. Some blood vessels contain a substantial population of medial constrictor receptors for acetylcholine… CONTINUE READING