Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey.

@article{StroessnerJohnson1992CholinergicCL,
  title={Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey.},
  author={H M Stroessner-Johnson and Peter R Rapp and David G. Amaral},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 5},
  pages={
          1936-44
        }
}
Quantitative studies were conducted to determine the number and size of cholinergic neurons in the medial septal nucleus of four aged (23-25 years old) and four young (10-12 years old) rhesus monkeys. All of the animals had been tested on an extensive battery of learning and memory tasks prior to these experiments. Two of the aged monkeys displayed a pattern of recognition memory deficits that resembled the effects of medial temporal lobe damage. The postmortem anatomical data were analyzed in… CONTINUE READING

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