Cholinergic and serotonergic effects on the P3 potential and recent memory.

@article{Meador1989CholinergicAS,
  title={Cholinergic and serotonergic effects on the P3 potential and recent memory.},
  author={Kimford J. Meador and David W. Loring and H. Clinton Davis and Kapil D. Sethi and Binduben Patel and Russell John Adams and EsterM. Hammond},
  journal={Journal of clinical and experimental neuropsychology},
  year={1989},
  volume={11 2},
  pages={
          252-60
        }
}
The effects of scopolamine (anticholinergic) and methysergide (antiserotonergic) on memory and long-latency auditory cognitive evoked potentials (EPs) were tested in 16 normal adults. Recent memory was impaired by both drugs. In contrast, scopolamine, but not methysergide, significantly delayed P3 latency and decreased P3 amplitude. Immediate memory and the earlier EP components (i.e., N1 and P2) were unaffected. The findings support the hypothesis that cholinergic neurons are important in the… CONTINUE READING
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