Cholinergic and non-cholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of rapid eye movement sleep.

@article{Quattrochi1998CholinergicAN,
  title={Cholinergic and non-cholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of rapid eye movement sleep.},
  author={James J. Quattrochi and Subimal Datta and J. Allan Hobson},
  journal={Neuroscience},
  year={1998},
  volume={83 4},
  pages={1123-36}
}
A single microinjection of the cholinergic agonist carbachol into the feline caudolateral parabrachial nucleus produces an immediate increase in state-independent ipsilateral ponto-geniculooccipital waves, followed by a long-term rapid eye movement sleep enhancement lasting 7-10 days. Using retrogradely-transported fluorescent carbachol-conjugated nanospheres and choline acetyltransferase immunohistochemistry, afferent projections to this injection site for long-term rapid eye movement sleep… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Brain StemIs location of anatomic structureStructure of locus ceruleus
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Brain StemIs location of anatomic structureraphe nuclei
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Using retrogradely - transported fluorescent carbachol - conjugated nanospheres and choline acetyltransferase immunohistochemistry , afferent projections to this injection site for long - term rapid eye movement sleep enhancement were mapped and quantified .
Using retrogradely - transported fluorescent carbachol - conjugated nanospheres and choline acetyltransferase immunohistochemistry , afferent projections to this injection site for long - term rapid eye movement sleep enhancement were mapped and quantified .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
7.5% ) , and pontine reticular formation ( 4.4 + /-
The retrogradely - labelled ( rhodamine+ ) cells in the pontine reticular formation and pedunculopontine tegmental nucleus contributed the predominant input to the parabrachial nucleus injection site ( 34.3 + /-
2.8% ) , and pontine reticular formation ( 3.2 + /-
The retrogradely - labelled ( rhodamine+ ) cells in the pontine reticular formation and pedunculopontine tegmental nucleus contributed the predominant input to the parabrachial nucleus injection site ( 34.3 + /-
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
2.8% ) , and pontine reticular formation ( 3.2 + /-
7.5% ) , and pontine reticular formation ( 4.4 + /-
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
The retrogradely - labelled ( rhodamine+ ) cells in the pontine reticular formation and pedunculopontine tegmental nucleus contributed the predominant input to the parabrachial nucleus injection site ( 34.3 + /-
A single microinjection of the cholinergic agonist carbachol into the feline caudolateral parabrachial nucleus produces an immediate increase in state - independent ipsilateral ponto - geniculooccipital waves , followed by a long - term rapid eye movement sleep enhancement lasting 7 - 10 days .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
Since the non - cholinergic input includes contributions from the locus coeruleus and raphe nuclei , it is probable that the caudolateral parabrachial nucleus contains cholinergic and aminergic afferent systems that participate in the long - term enhancement of rapid eye movement sleep .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
A single microinjection of the cholinergic agonist carbachol into the feline caudolateral parabrachial nucleus produces an immediate increase in state - independent ipsilateral ponto - geniculooccipital waves , followed by a long - term rapid eye movement sleep enhancement lasting 7 - 10 days .
By comparison with findings of afferent input to the induction site for short - latency rapid eye movement sleep in the anterodorsal pontine reticular formation , the parabrachial nucleus injection site is characterized by a similar proportion of afferents , except that the raphe nuclei were found to provide more than a two - fold greater input .
The retrogradely - labelled ( rhodamine+ ) cells in the pontine reticular formation and pedunculopontine tegmental nucleus contributed the predominant input to the parabrachial nucleus injection site ( 34.3 + /-
A single microinjection of the cholinergic agonist carbachol into the feline caudolateral parabrachial nucleus produces an immediate increase in state - independent ipsilateral ponto - geniculooccipital waves , followed by a long - term rapid eye movement sleep enhancement lasting 7 - 10 days .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
Six regions in the brain stem contained retrogradely - labelled cells : the raphe nuclei , locus coeruleus , laterodorsal tegmental nucleus , pedunculopontine tegmental nucleus , parabrachial nucleus , and the pontine reticular formation .
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