Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme

@article{Schaeffer2008CholinergicAG,
  title={Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme},
  author={Evelin Lisete Schaeffer and Wagner F. Gattaz},
  journal={Psychopharmacology},
  year={2008},
  volume={198},
  pages={1-27}
}
Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence suggests the involvement of phospholipase A2 (PLA2) enzyme in memory impairment and neurodegeneration in AD via actions on both cholinergic and glutamatergic systems. To review cholinergic and… CONTINUE READING
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