Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells.


The Abeta peptide of Alzheimer disease is derived from the proteolytic processing of the amyloid precursor proteins (APP), which are considered type I transmembrane glycoproteins. Recently, however, soluble forms of full-length APP were also detected in several systems including chromaffin granules. In this report we used antisera specific for the… (More)


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