Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism

@inproceedings{George2016CholinergicSP,
  title={Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism},
  author={Junu A. George and Ghada Hassan Bashir and Mohammed M. Qureshi and Yassir A. Mohamed and Jamil R Azzi and Basel K. al-Ramadi and Maria J. Fern{\'a}ndez-Cabezudo},
  booktitle={Front. Immunol.},
  year={2016}
}
Type I diabetes (T1D) results from T cell-mediated damage of pancreatic β-cells and loss of insulin production. The cholinergic anti-inflammatory pathway represents a physiological link connecting the central nervous and immune systems via vagus nerve, and functions to control the release of proinflammatory cytokines. Using the multiple low-dose streptozotocin (MLD-STZ) model to induce experimental autoimmune diabetes, we investigated the potential of regulating the development of hyperglycemia… CONTINUE READING
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