Cholinergic Neurons in Nucleus Subputaminalis in Primary Progressive Aphasia

  title={Cholinergic Neurons in Nucleus Subputaminalis in Primary Progressive Aphasia},
  author={H. Hamodat and J. Fisk and S. Darvesh},
  journal={Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques},
  pages={174 - 183}
  • H. Hamodat, J. Fisk, S. Darvesh
  • Published 2019
  • Medicine, Biology
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
ABSTRACT: Background: Primary Progressive Aphasia (PPA) is a syndrome characterized by an isolated impairment of language function at disease onset. The cholinergic system is implicated in language function and cholinergic deficits are seen in the brains of individuals with PPA. One major source of cholinergic innervation of the cerebral cortex is the nucleus basalis of Meynert (NBM) within which lies the nucleus subputaminalis (NSP). This nucleus is postulated to be involved in language… Expand
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