Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding

@inproceedings{Risacher2013CholinergicEO,
  title={Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding},
  author={Shannon L. Risacher and Yang Wang and Heather Wishart and Laura A. Rabin and L. A. Flashman and Brenna C. McDonald and John D. West and Robert B. Santulli and Andrew J. Saykin},
  booktitle={Front. Psychiatry},
  year={2013}
}
  • Shannon L. Risacher, Yang Wang, +6 authors Andrew J. Saykin
  • Published in Front. Psychiatry 2013
  • Psychology, Medicine
  • OBJECTIVE To determine the physiological impact of treatment with donepezil (Aricept) on neural circuitry supporting episodic memory encoding in patients with amnestic mild cognitive impairment (MCI) using functional magnetic resonance imaging (fMRI). METHODS Eighteen patients with MCI and 20 age-matched healthy controls (HC) were scanned twice while performing an event-related verbal episodic encoding task. MCI participants were scanned before treatment and after approximately 3 months on… CONTINUE READING

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