Cholinergic Enhancement Augments Magnitude and Specificity of Visual Perceptual Learning in Healthy Humans

@article{Rokem2010CholinergicEA,
  title={Cholinergic Enhancement Augments Magnitude and Specificity of Visual Perceptual Learning in Healthy Humans},
  author={Ariel Rokem and Michael A. Silver},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={1723-1728}
}
Learning through experience underlies the ability to adapt to novel tasks and unfamiliar environments. However, learning must be regulated so that relevant aspects of the environment are selectively encoded. Acetylcholine (ACh) has been suggested to regulate learning by enhancing the responses of sensory cortical neurons to behaviorally relevant stimuli. In this study, we increased synaptic levels of ACh in the brains of healthy human subjects with the cholinesterase inhibitor donepezil (trade… CONTINUE READING

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