Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.

@article{Wozniak2015CholineSI,
  title={Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.},
  author={Jeffrey R. Wozniak and A J Fuglestad and Judith K. Eckerle and Birgit A. Fink and Heather L Hoecker and Christopher J Boys and Joshua P Radke and Maria G. Kroupina and Neely C. Miller and Ann M. Brearley and Steven H Zeisel and Michael K. Georgieff},
  journal={The American journal of clinical nutrition},
  year={2015},
  volume={102 5},
  pages={
          1113-25
        }
}
BACKGROUND Fetal alcohol spectrum disorders (FASDs) are conditions characterized by physical anomalies, neurodevelopmental abnormalities, and neurocognitive deficits, including intellectual, executive, and memory deficits. There are no specific biological treatments for FASDs, but rodent models have shown that prenatal or postnatal choline supplementation reduces cognitive and behavioral deficits. Potential mechanisms include phospholipid production for axonal growth and myelination… CONTINUE READING
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