Choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices.

@article{Fowler1995CholineSF,
  title={Choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices.},
  author={John C. Fowler},
  journal={Neuroscience letters},
  year={1995},
  volume={197 2},
  pages={97-100}
}
Substituting choline for sodium resulted in an extracellularly recorded transient depolarization and increased efflux of glutamate and adenosine from rat hippocampal slices. The depolarization was blocked by a combination of NMDA and non-NMDA antagonists, MK-801 (10 microM) and 6,7-dinitroquinoxaline-2,3-dione (DNQX, 50 microM). Adenosine release was blocked by MK-801 alone. These data suggest that glutamate released as a result of the sodium removal acts at NMDA and non-NMDA glutamate… CONTINUE READING

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