Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial

@article{Spector2008CholinestabilizedOA,
  title={Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial},
  author={Tim D. Spector and Mario R. Calomme and Simon H.C. Anderson and Gail Clement and Liisa Bevan and Nathalie Demeester and Rami Swaminathan and Ravin Jugdaohsingh and Dirk A. Vanden Berghe and Jonathan J. S. Powell},
  journal={BMC Musculoskeletal Disorders},
  year={2008},
  volume={9},
  pages={85 - 85}
}
BACKGROUND Mounting evidence supports a physiological role for silicon (Si) as orthosilicic acid (OSA, Si(OH)4) in bone formation. The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of bone turnover and bone mineral density (BMD) was investigated in a double-blind placebo-controlled trial. METHODS Over 12-months, 136 women out of 184 randomized (T-score spine < -1.5) completed the study and received, daily, 1000 mg Ca and 20 microg cholecalciferol (Vit D3) and three… CONTINUE READING
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