Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia

@article{Yilmaz2010CholineOC,
  title={Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia},
  author={Zeki Yilmaz and Yesim Ozarda and Mehmet Ege Cansev and O. C. Eralp and Meriç Kocaturk and Ismail Hakki Ulus},
  journal={Blood Coagulation \& Fibrinolysis},
  year={2010},
  volume={21},
  pages={339–348}
}
Sepsis/endotoxemia causes platelet dysfunctions, abnormalities in coagulation and hemostatic mechanisms leading to organ dysfunctions and mortality. Choline prevents organ injury and improves survival during endotoxemia. The main objective of the present study was to determine the effects of choline or cytidine-5′-diphosphocholine (CDP-choline) on endotoxin-induced activation of coagulation and development of disseminated intravascular coagulation (DIC). Dogs were treated intravenously (i.v… Expand
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