Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture.

@article{Albright1996CholineDI,
  title={Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture.},
  author={Craig D. Albright and Runzhong Liu and Thelma Bethea and Kerry Ann da Costa and Rudolf I. Salganik and Steven H Zeisel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1996},
  volume={10 4},
  pages={
          510-6
        }
}
Immortalized CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, had increased numbers of cells with strand breaks in genomic DNA (terminal dUTP end labeling) when grown in 0 Micron choline (67-73% of cells) than when grown in 70 Micron choline (2-3% of cells). Internucleosomal fragmentation of DNA (DNA ladders) was detected in cells grown with 5 Micron and 0 Micron choline for 72h. Cells treated with 0 or 5 Micron choline for 72h detached from the substrate in… CONTINUE READING
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