Choline chloride in methylphenidate- and apomorphine-induced stereotypy.

  title={Choline chloride in methylphenidate- and apomorphine-induced stereotypy.},
  author={Kenneth L. Davis and Leo E. Hollister and Adela L. Vento and Susan C. Simonton},
  journal={Life sciences},
  volume={22 24},

Dimethylaminoethanol (Deanol): Effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia

DMAE did not reduce apomorphine-induced stereotypy in animals previously exposed to haloperidol and presumed to have postsynaptic dopamine receptor supersensitivity, and choline chloride may be more effective than DMAE at augmenting striatal cholinergic activity.

Cholinomimetics and memory. The effect of choline chloride.

Young normal subjects received 16 g of choline chloride in a double-blind A-B-A design and the results suggest that the effect of lower doses of Choline on long-term memory should be evaluated.

Effect of choline on central dopaminergic function in normal subjects

The data suggest that cholinergic mechanisms may enhance hypothalamic-pituitary dopaminergic function in man in contrast to their inhibitory effect on dopamine function in the basal ganglia.

Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man

The scope and complexity of the actions of physostigmine suggest that the neurochemical basis of these effects might extend beyond the ability of the drug to increase cholinergic activity.

Delirium and stereotypy from anticholinergic antiparkinson drugs

  • A. V. KulikR. Wilbur
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1982

Development of cholinergic drugs for the treatment of Alzheimer's disease

The hypothesis that cholinergic deficits are manifested in symptoms of AD is supported and administration of cholinomimetic agents is a rational treatment strategy in AD.

The cholinergic hypothesis of geriatric memory dysfunction.

Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to

Cholinergic systems and alzheimer's disease

Findings concerning the roles of nerve growth factor, “excitotoxic” amino acids, and amyloid deposition in AD migh lead to mroe fruitful therapeutic approaches.

Tardive dyskinesia: clinical, biological, and pharmacological perspectives.

Tardive dyskinesia is the most troublesome side effect of long-term neuroleptic therapy, the best available pharmacological treatment for chronic schizophrenia, and a variety of pharmacological agents have been investigated as possible treatments, including agents that decrease central dopaminergic activity, cholinomimetics, and agonists of gamma-aminobutyric acid.



Central effects of anticholergic drugs measured by the apomorphine gnawing test in mice.

Since the apomorphine gnawing behaviour is most probably related to an interaction with central dopamine receptors, these findings suggest there is a central counter balancing dopaminergic-cholinergic system.

Brain acetylcholine: control by dietary choline.

The increases in brain acetylcholine after treatment with physositigmine (an inhibitor of actylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylCholine synthesis.