Choline chloride in methylphenidate- and apomorphine-induced stereotypy.

@article{Davis1978CholineCI,
  title={Choline chloride in methylphenidate- and apomorphine-induced stereotypy.},
  author={Kenneth L. Davis and Leo E. Hollister and Adela L. Vento and Susan C. Simonton},
  journal={Life sciences},
  year={1978},
  volume={22 24},
  pages={
          2171-7
        }
}
Abstract The effect of choline chloride on apomorphine- and methylphenidate-induced stereotypy in rats was tested. Subcutaneous administration of a single dose of choline chloride significantly reduced apomorphine-induced stereotypy. These results could not be attributed to a nonspecific obtunding effect of choline chloride, and indicate that choline chloride may increase central cholinergic activity. However, neither acute nor chronic oral administration of choline chloride reversed… Expand
13 Citations
Lack of effect of choline and narcotic antagonists upon apomorphine discrimination.
  • M. Schechter
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1980
TLDR
Only haloperidol pretreatment was observed to significantly alter the rats' ability to discriminate apomorphine, and the possible mechanism(s) of action of narcotic antagonist and cholinomimetic drug effects upon dopaminergically mediated behaviors is discussed. Expand
Dimethylaminoethanol (Deanol): Effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia
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DMAE did not reduce apomorphine-induced stereotypy in animals previously exposed to haloperidol and presumed to have postsynaptic dopamine receptor supersensitivity, and choline chloride may be more effective than DMAE at augmenting striatal cholinergic activity. Expand
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Young normal subjects received 16 g of choline chloride in a double-blind A-B-A design and the results suggest that the effect of lower doses of Choline on long-term memory should be evaluated. Expand
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The data suggest that cholinergic mechanisms may enhance hypothalamic-pituitary dopaminergic function in man in contrast to their inhibitory effect on dopamine function in the basal ganglia. Expand
Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man
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The scope and complexity of the actions of physostigmine suggest that the neurochemical basis of these effects might extend beyond the ability of the drug to increase cholinergic activity. Expand
Delirium and stereotypy from anticholinergic antiparkinson drugs
  • A. V. Kulik, R. Wilbur
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1982
TLDR
It is proposed, on the basis of a review of animal and clinical data, that stereotypies in delirious patients are related to muscarinic blockade in the central nervous system, which is used to explain repetitive motor automatisms which are seen in Alzheimer's disease. Expand
Development of cholinergic drugs for the treatment of Alzheimer's disease
Alzheimer's Disease (AD) is characterized neurochemically by a profound loss of choline acetyl transferase activity and histologically by a selective degeneration of cholinergic neurons originatingExpand
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Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made toExpand
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TLDR
Findings concerning the roles of nerve growth factor, “excitotoxic” amino acids, and amyloid deposition in AD migh lead to mroe fruitful therapeutic approaches. Expand
Ionic liquids for oral insulin delivery
TLDR
The development of a highly effective oral insulin formulation using choline and geranate (CAGE) ionic liquid that significantly enhanced oral insulin absorption by efficiently circumventing the gastrointestinal barriers and demonstrated good stability at room temperature and under refrigeration is reported. Expand
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