Choline chloride in methylphenidate- and apomorphine-induced stereotypy.

  title={Choline chloride in methylphenidate- and apomorphine-induced stereotypy.},
  author={Kenneth L. Davis and Leo E. Hollister and Adela L. Vento and Susan C. Simonton},
  journal={Life sciences},
  volume={22 24},
Abstract The effect of choline chloride on apomorphine- and methylphenidate-induced stereotypy in rats was tested. Subcutaneous administration of a single dose of choline chloride significantly reduced apomorphine-induced stereotypy. These results could not be attributed to a nonspecific obtunding effect of choline chloride, and indicate that choline chloride may increase central cholinergic activity. However, neither acute nor chronic oral administration of choline chloride reversed… Expand
13 Citations
Lack of effect of choline and narcotic antagonists upon apomorphine discrimination.
  • M. Schechter
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1980
Only haloperidol pretreatment was observed to significantly alter the rats' ability to discriminate apomorphine, and the possible mechanism(s) of action of narcotic antagonist and cholinomimetic drug effects upon dopaminergically mediated behaviors is discussed. Expand
Dimethylaminoethanol (Deanol): Effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia
DMAE did not reduce apomorphine-induced stereotypy in animals previously exposed to haloperidol and presumed to have postsynaptic dopamine receptor supersensitivity, and choline chloride may be more effective than DMAE at augmenting striatal cholinergic activity. Expand
Cholinomimetics and memory. The effect of choline chloride.
Young normal subjects received 16 g of choline chloride in a double-blind A-B-A design and the results suggest that the effect of lower doses of Choline on long-term memory should be evaluated. Expand
Effect of choline on central dopaminergic function in normal subjects
The data suggest that cholinergic mechanisms may enhance hypothalamic-pituitary dopaminergic function in man in contrast to their inhibitory effect on dopamine function in the basal ganglia. Expand
Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man
The scope and complexity of the actions of physostigmine suggest that the neurochemical basis of these effects might extend beyond the ability of the drug to increase cholinergic activity. Expand
Delirium and stereotypy from anticholinergic antiparkinson drugs
  • A. V. Kulik, R. Wilbur
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1982
It is proposed, on the basis of a review of animal and clinical data, that stereotypies in delirious patients are related to muscarinic blockade in the central nervous system, which is used to explain repetitive motor automatisms which are seen in Alzheimer's disease. Expand
Development of cholinergic drugs for the treatment of Alzheimer's disease
Alzheimer's Disease (AD) is characterized neurochemically by a profound loss of choline acetyl transferase activity and histologically by a selective degeneration of cholinergic neurons originatingExpand
The cholinergic hypothesis of geriatric memory dysfunction.
Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made toExpand
Cholinergic systems and alzheimer's disease
Findings concerning the roles of nerve growth factor, “excitotoxic” amino acids, and amyloid deposition in AD migh lead to mroe fruitful therapeutic approaches. Expand
Ionic liquids for oral insulin delivery
The development of a highly effective oral insulin formulation using choline and geranate (CAGE) ionic liquid that significantly enhanced oral insulin absorption by efficiently circumventing the gastrointestinal barriers and demonstrated good stability at room temperature and under refrigeration is reported. Expand


Brain acetylcholine: increase after systemic choline administration.
Observations suggest that precursor availability may influence brain ACh synthesis, just as brain tryptophan and tyrosine levels have previously been shown to control the synthesis of brain serotonin and catecholamines. Expand
Central effects of anticholergic drugs measured by the apomorphine gnawing test in mice.
Since the apomorphine gnawing behaviour is most probably related to an interaction with central dopamine receptors, these findings suggest there is a central counter balancing dopaminergic-cholinergic system. Expand
Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain.
Abstract Behavioral studies on the effects of amphetamine, methamphetamine, phenmetrazine, pipradrol, NCA and methylphenidate administered to rats pretreated with reserpine or αmethyltyrosine andExpand
The role of telencephalic dopaminergic systems in the mediation of apomorphine-stereotyped behaviour.
Stereotypy was reduced, both during the acute and chronic stages following ablation of the nucleus amygdaloideus centralis, but was not modified by lesion of the stria terminalis, and the possibility that apomorphine may modify pre- as well as post-synaptic mechanisms is considered. Expand
Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity.
D-Amphetamine proved more effective than dopamine in producing locomotor stimulation, whereas both stimulant and depressant effects were observed following injection of apomorphine into the nucleus accumbens. Expand
Choline in tardive dyskinesia and Huntington's disease.
Choline chloride may ameliorate these movement disorders by increasing central cholinergic activity, but other mechanisms are possible, and its practical importance as a treatment needs further elucidation. Expand
Increase in tissue concentration of acetylcholine in guinea pigs in vivo induced by administration of choline.
It is suggested that raising the concentration of choline in plasma will accelerate the formation of acetylcholine in the organs cited, and no significant increase in concentration of Choline or acetylCholine occurred in brain. Expand
Brain acetylcholine: control by dietary choline.
The increases in brain acetylcholine after treatment with physositigmine (an inhibitor of actylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylCholine synthesis. Expand
Transport of choline from plasma to cerebrospinal fluid in the rabbit with reference to the origin of choline and to acetylcholine metabolism in brain
It is suggested that in rabbit, free and derived choline in plasma are supplied to the brain in equal amounts and that choline is transported from plasma, via the extracellular space of the brain to CSF. Expand