Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.

@article{Jones1999CholineAT,
  title={Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.},
  author={J. P. Jones and W. Meck and C. L. Williams and W. A. Wilson and H. Swartzwelder},
  journal={Brain research. Developmental brain research},
  year={1999},
  volume={118 1-2},
  pages={
          159-67
        }
}
Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring. To determine if the behavioral effects of choline are related to physiological changes in hippocampus, the effect of perinatal choline supplementation or deficiency on long-term potentiation (LTP) was examined in hippocampal slices of 6-8 and 12-14 month old rats born to dams consuming a control, choline-supplemented, or a choline-free diet during pregnancy… Expand
Prenatal choline supplementation alters hippocampal N-methyl-d-aspartate receptor-mediated neurotransmission in adult rats
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Evoked NMDA receptor-mediated pEPSPs were enhanced in slices from prenatally choline supplemented relative to controls in both male and female rats, with greatest differences at the low end of the input-output curve. Expand
Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood.
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The results suggest that GABA receptor-mediated inhibition remains intact after prenatal choline manipulations, and that enhancement of the excitatory responsiveness of hippocampal circuits in slices from prenatally choline supplemented rats may be related in part to an increase in cholinergic tone within the CA1 circuit. Expand
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While the upregulated CHT expression during the period of prenatal choline deficiency may be considered as a compensatory mechanism that could enhance ACh synthesis when choline supply is low, the persistent upregulation ofCHT expression subsequent to the briefperiod of prenatal deprivation of choline in utero might be beneficial during choline deficiencies in adulthood. Expand
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The main finding was that SUP rats displayed increased power levels of gamma band oscillations during all phases of the sleep/wake cycle, and was discussed within the context of a general review of neuronal oscillations and synchronization across multiple brain regions in relation to sleep-dependent memory consolidation in the hippocampus. Expand
Protective Effects of Prenatal Choline Supplementation on Seizure-Induced Memory Impairment
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It is demonstrated that prenatal choline supplementation can protect rats against memory deficits induced by status epilepticus, and neither the seizures nor the prenatal availability of choline had any effect on hippocampal choline acetyltransferase or acetylcholinesterase activities. Expand
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The data suggest that the behavioral consequences of early dietary availability of choline may involve the modification of the discriminative abilities used to attend to stimuli that demarcate the end of one trial and the start of another as well as the capacity for remembering the locations that have been visited during a trial. Expand
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague–Dawley rats
TLDR
Assessment of sensory inhibition in Sprague-Dawley rats gestated on normal, deficient, deficient or supplemented choline in the maternal diet during the critical period for cholinergic cell development suggests that attention to maternal choline levels for human pregnancy may be important to the normal functioning of the offspring. Expand
Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero
TLDR
The in utero availability of an essential nutrient, choline, causes differential behavioral and neuroplastic sensitivity to the adult choline supply in male Sprague-Dawley rats. Expand
Choline Availability During Embryonic Development Alters the Localization of Calretinin in Developing and Aging Mouse Hippocampus
Abstract Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring. In the presentExpand
Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats
TLDR
Findings provide the first evidence that prenatal choline supplementation causes changes in exploratory behaviors over the lifespan and preserves some features of hippocampal plasticity that can be seen even at 2 years of age. Expand
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TLDR
Observations indicate that prenatal dietary manipulation of the amino acid, choline, leads to subsequent significant alterations of LTP induction threshold in adult animals. Expand
Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory.
TLDR
Compared to control littermates, perinatal choline-treated rats showed more accurate performance on both working and reference memory components of the task and it appears that choline induced performance differences are due to long-term enhancement of spatial memory capacity and precision. Expand
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TLDR
Data are consistent with the hypothesis that supplementation with choline chloride during early development leads to an increase in the size of cell bodies of NTR-immunoreactive cells in the basal forebrain and that this change may contribute to long-term improvement in spatial memory. Expand
Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring
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  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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TLDR
Results show that prenatal choline supplementation up‐regulates basal and receptor‐stimulated PLD activity in the hippocampus during postnatal development, and increases hippocampal phospholipase D activity of the offspring. Expand
Prenatal availability of choline modifies development of the hippocampal cholinergic system
TLDR
The data show a complex adaptive response of the hippocampal cholinergic system to prenatal choline availability and provide a novel example of developmental plasticity in the nervous system governed by the supply of a single nutrient. Expand
Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory
TLDR
The results indicated that perinatal choline supplementation increased rats' sensitivity to the 20 s temporal criterion during baseline training and facilitated the clock speed enhancing effects of nicotine during drug testing. Expand
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TLDR
The data demonstrate that perinatal choline supplementation causes long-term facilitative effects on working and reference memory components of a 12-arm radial maze task, and alternations of muscarinic receptor density as indexed by [3H]quinuclidinyl benzilate (QNB) binding and choline acetyltransferase (ChAT) levels in the hippocampus and frontal cortex of adult rats. Expand
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This work was aimed at analyzing the effects of perinatal choline supplementation on the development of spatial abilities and upon adult performance. Choline supplementation (3.5 g/L in 0.02 MExpand
Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats
TLDR
It is indicated that prenatal choline supplementation facilitates cognitive function across the lifespan, whereas prenatal Choline deficiency impairs divided attention and accelerates age-related declines in temporal processing. Expand
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