Choline antagonism of methotrexate liver toxicity in the rat.

@article{FreemanNarrod1977CholineAO,
  title={Choline antagonism of methotrexate liver toxicity in the rat.},
  author={M. Freeman-Narrod},
  journal={Medical and pediatric oncology},
  year={1977},
  volume={3 1},
  pages={
          9-14
        }
}
Because of the frequent reports of hepatic toxicity associated with long-term administration of methotrexate, a rat model was developed utilizing daily methotrexate administration. This model revealed an incidence of fatty metamorphosis of over 80 percent, atrophy and necrosis of 30 percent, and fibrosis of 10 percent. Fatty liver changes did not differ substantially from control animals in those animals receiving long-term thydroxyurea, an agent which, like methotrexate, inhibits DNA synthesis… Expand
11 Citations
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The currently available animal data on choline and hippocampal development are compelling, but studies are needed to determine whether the same is true in humans. Expand
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