Choline and Fructooligosaccharide: Non-alcoholic Fatty Liver Disease, Cardiac Fat Deposition, and Oxidative Stress Markers

Abstract

This study investigates the treatment of non-alcoholic fatty liver disease (NAFLD) in rats with choline and fructooligosaccharide (FOS). The healthy control group received standard diet. The other three groups consisted of animals with NAFLD. Group Estr received standard diet; group Echo received standard diet plus choline (3 g/100 g diet); and group Efos received standard diet plus FOS (10 g/100 g diet). Food intake, weight, urinary nitrogen, urinary ammonia, total cholesterol, serum triacylglyceride, liver and heart weights, tissue nitrogen, tissue fat, vitamin E, TBARS, and reduced glutathione (GSH) were measured in hepatic and heart tissue. Choline and FOS treatments resulted in total mean fat reduction in liver and heart tissue of 0.2 and 1.7 g, respectively. Both treatments were equally effective in reducing hepatic and cardiac steatosis. There were no differences in the TBARS level among experimental and control groups, indicating that the proposed treatments had no added protection against free radicals. While all experimental groups had increased vitamin E and GSH levels, choline treatment led to a significant increase compared to control.

DOI: 10.4137/NMI.S24385

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Cite this paper

@inproceedings{Haubert2015CholineAF, title={Choline and Fructooligosaccharide: Non-alcoholic Fatty Liver Disease, Cardiac Fat Deposition, and Oxidative Stress Markers}, author={Nadia Juliana Beraldo Goulart Borges Haubert and J{\'u}lio S{\'e}rgio Marchini and Selma Freire Carvalho Cunha and Vivian Miguel Marques Suen and Gilberto Jo{\~a}o Padovan and Alceu Afonso Jord{\~a}o and Claudia Maria Meirelles Marchini Alves and J{\'u}lio Flavio Meirelles Marchini and H{\'e}lio Vannucchi}, booktitle={Nutrition and metabolic insights}, year={2015} }