Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response.

@article{Mancama2007CholineAV,
  title={Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response.},
  author={Dalu Mancama and Ignacio Mata and RobertW. Kerwin and Mar{\'i}a Jes{\'u}s Arranz},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2007},
  volume={144B 7},
  pages={
          849-53
        }
}
Choline acetyltransferase (ChAt) is extensively distributed throughout the CNS where, by catalyzing acetylcholine synthesis, it participates in modulating wide-ranging cholinergic-dependent functions including cognitive performance, sleep, arousal, movement, and visual information processing. Recently, compelling evidence has mounted implicating ChAt in schizophrenia. In particular, studies have identified significant reductions in ChAt activity in the nucleus accumbens and pontine tegmentum of… CONTINUE READING
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