Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response

@article{Mancama2007CholineAV,
  title={Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response},
  author={D. Mancama and I. Mata and R. Kerwin and M. Arranz},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2007},
  volume={144B}
}
  • D. Mancama, I. Mata, +1 author M. Arranz
  • Published 2007
  • Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Choline acetyltransferase (ChAt) is extensively distributed throughout the CNS where, by catalyzing acetylcholine synthesis, it participates in modulating wide‐ranging cholinergic‐dependent functions including cognitive performance, sleep, arousal, movement, and visual information processing. Recently, compelling evidence has mounted implicating ChAt in schizophrenia. In particular, studies have identified significant reductions in ChAt activity in the nucleus accumbens and pontine tegmentum of… Expand
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