Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response

  title={Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response},
  author={Dalu T Mancama and Ignacio F. Mata and R. W. Kerwin and Mar{\'i}a Jes{\'u}s Arranz},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  • D. MancamaI. Mata M. Arranz
  • Published 5 October 2007
  • Psychology, Biology
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Choline acetyltransferase (ChAt) is extensively distributed throughout the CNS where, by catalyzing acetylcholine synthesis, it participates in modulating wide‐ranging cholinergic‐dependent functions including cognitive performance, sleep, arousal, movement, and visual information processing. Recently, compelling evidence has mounted implicating ChAt in schizophrenia. In particular, studies have identified significant reductions in ChAt activity in the nucleus accumbens and pontine tegmentum of… 

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