Choline acetyltransferase activity of rat synaptosomes is sensitive to enflurane, but not halothane or isoflurane.

@article{Griffiths1994CholineAA,
  title={Choline acetyltransferase activity of rat synaptosomes is sensitive to enflurane, but not halothane or isoflurane.},
  author={R. Griffiths and E. Boyle and J. Greiff and D. Rowbotham and R. Norman},
  journal={British journal of anaesthesia},
  year={1994},
  volume={72 5},
  pages={
          577-80
        }
}
We have examined the activity of choline acetyltransferase (ChAT) in rat cortical synaptosomes in the presence of three volatile anaesthetic agents: enflurane, halothane and isoflurane. The Michaelis constant Km, for choline was reduced significantly (P = 0.012) in the presence of 6.5% enflurane (3 rat MAC) compared with control samples exposed to carrier air only, while maximum reaction velocity (Vmax) remained unaltered. The reduction in Km was also significant at enflurane concentrations of… Expand

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