Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system

  title={Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system},
  author={Yoshio Oda},
  journal={Pathology International},
  • Y. Oda
  • Published 1 November 1999
  • Biology
  • Pathology International
Choline acetyltransferase (ChAT), the enzyme responsible for the biosynthesis of acetylcholine, is presently the most specific indicator for monitoring the functional state of cholinergic neurones in the central and peripheral nervous systems. ChAT is a single‐strand globular protein. The enzyme is synthesized in the perikaryon of cholinergic neurones and transported to the nerve terminals probably by both slow and rapid axoplasmic flows. ChAT exists in at least two forms in cholinergic nerve… 

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