• Corpus ID: 718008

Choline , Folate and Homocysteine Are Inter-Related Nutrients

  title={Choline , Folate and Homocysteine Are Inter-Related Nutrients},
  author={Steven H Zeisel},
Choline is a dietary component essential for normal function of all cells. In 1998 the National Academy of Sciences, USA, issued a report identifying choline as a required nutrient for humans and recommended daily intake amounts. In ongoing studies we are finding that men have a higher requirement than do postmenopausal women, who in turn need more than premenopausal women. Pregnancy and lactation are periods when maternal reserves of choline are depleted. At the same time, the availability of… 

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Choline: an important nutrient in brain development, liver function and carcinogenesis.
  • S. Zeisel
  • Biology
    Journal of the American College of Nutrition
  • 1992
It was found that choline deficiency was associated with the accumulation of 1,2-diacylglycerol, an activator of protein kinase C-mediated signal transduction, which may explain why choline-deficient rats spontaneously develop hepatocarcinoma.
Choline, an essential nutrient for humans.
  • S. Zeisel, K. da Costa, A. Beiser
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
Brain folates and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate.
  • E. Alonso-Aperte, G. Varela-Moreiras
  • Medicine, Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1996
The possibility that choline deficiency and MTX treatment appear to impair the capacity of tissues, either a peripheral one as liver or a central one as brain, to incorporate folate is discussed on the basis of the possibility that this may be reversed through restoration of an adequate choline diet.
Choline and human nutrition.
It is believed that the normal human diet provides sufficient choline to sustain healthy organ function, however, vulnerable populations may become choline deficient, including the growing infant, the pregnant or lactating woman, the cirrhotic, and the patient fed intravenously.
Concentrations of choline-containing compounds and betaine in common foods.
The choline concentration of 145 common foods was analyzed using liquid chromatography-mass spectrometry to examine the relationship between dietary folic acid and cancer or heart disease and betaine, a choline derivative, was examined.
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Pregnant rats and lactating rats were the most sensitive to choline deficiency, and pregnant rats fed a choline-deficient diet had significantly great diminution of hepatic phosphorylcholine than did nonmated females.
Effect of experimental folate deficiency on lipid metabolism in liver and brain
Although the low concentrations of folate was the main nutritional change in the deprived animals, changes with respect to vitamin B12 and maybe also choline cannot be excluded, and some of the changes in folate deficiency, i.e. fatty liver and decreased biosynthesis of liver phospholipids may be due to a precipitated deficiency of lipotropic agents.
Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet.
Potential metabolites of choline that might mediate the observed effects on brain development in the rats are identified.
Developmental changes in rat blood choline concentration.
Dietary intake of choline contributes to the maintenance of high serum choline concentrations in the neonatal rat, and the age-related acceleration in choline's conversion into betaine probably tends to diminish unesterified choline concentration in the rat.