Cholesteryl octanoate breath test. Preliminary studies on a new noninvasive test of human pancreatic exocrine function.

@article{Cole1987CholesterylOB,
  title={Cholesteryl octanoate breath test. Preliminary studies on a new noninvasive test of human pancreatic exocrine function.},
  author={Solon R. Cole and Simona W. Rossi and Audrey Stern and AlanF. Hofmann},
  journal={Gastroenterology},
  year={1987},
  volume={93 6},
  pages={
          1372-80
        }
}
A new breath test for noninvasive assessment of pancreatic exocrine function in humans was developed. The test is based on the hydrolysis of cholesteryl-[1-14C]octanoate by pancreatic carboxyl ester lipase (cholesterol esterase) with subsequent absorption and hepatic metabolism of the liberated octanoate to 14CO2. The rate at which 14CO2 appears in breath appeared to be proportional to the rate of hydrolysis. The substrate is administered as a gum acacia stabilized emulsion of vegetable oil (18… CONTINUE READING
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