Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.

@article{Ding2005CholesterylHA,
  title={Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.},
  author={Wu-xiao Ding and Xian-Rong Qi and Ping Li and Yoshie Maitani and Tsuneji Nagai},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={300 1-2},
  pages={38-47}
}
In the present study, cholesteryl hemisuccinate (CHEMS) was evaluated for use as a membrane stabilizer in dipalmitoylphosphatidylcholine (DPPC) liposomes. Differential scanning calorimetry (DSC) and a calcein release study showed that CHEMS was more effective than cholesterol (CHOL) in increasing DPPC membrane stability. The findings of Fourier transform infrared spectroscopy (FT-IR) also suggested that CHEMS interacts with DPPC via both hydrogen bonding and electrostatic interaction. More… CONTINUE READING

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